Protein Crystallographer

SoseiHeptares Cambridge Royaume-Uni
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Description de l'entreprise

Sosei Heptares is an international biopharmaceutical company with a mission to make a significant contribution to improving the quality of life and health of people around the world. To achieve this, we will discover, design, and develop the most innovative and effective medicines for patients worldwide, through our world-leading patent-protected technology and platform.

Our core focus is on the discovery and early development of new medicines originating from our proprietary G Protein-Coupled Receptor (GPCR) targeted StaR® technology and Structure Based Drug Design (SBDD) platform capabilities. Today, we are advancing a broad and deep pipeline of novel medicines across multiple therapeutic areas, including neurology, immunology, gastroenterology, and inflammation diseases.

We have established partnerships with some of the world’s leading pharmaceutical companies and multiple emerging technology companies, including AbbVie, AstraZeneca, Biohaven, Genentech (Roche), GSK, Neurocrine Biosciences, Novartis, Pfizer, Takeda and Verily.

Sosei Heptares is headquartered in Tokyo, Japan with corporate and R&D facilities in London and Cambridge, UK. We have approximately 170 employees based at our state-of-the-art R&D research centre at Granta Park, Cambridge. The size of our company ensures optimum agility and transparent linkage between all activities from early discovery through to clinical development.

For more information, please visit LinkedIn: @soseiheptaresco | Twitter: @soseiheptaresco | YouTube: @soseiheptaresco


We are currently seeking an experienced protein crystallographer to join the crystallography team within the Biomolecular Structure department responsible for the structure determination of membrane proteins to support Sosei Heptares’ drug discovery efforts.

This is an exceptional opportunity to participate in pioneering science with an Industry-leading Drug Discovery company.

The successful candidate is expected to:

  • Express and purify soluble and integral membrane proteins for biophysical and structural characterisation
  • Set up and optimise crystallisation experiments
  • Screen crystals and collect diffraction data remotely at synchrotron sources
  • Determine, build, refine and validate crystal structures
  • Maintain and update crystallographic software and pipelines within a Linux environment
  • Propose, develop, implement, optimise, and maintain workflows and pipelines to accelerate structure determination using X-ray crystallography
  • Prepare and effectively present results (written and oral) to project teams (internal and external)
  • Have strong interpersonal skills and interact effectively with collaborators (internal and external) across a wide range of disciplines including Pharmacology, Medicinal Chemistry, and Computational Chemistry


Our preferred candidate will have the following:

  • PhD in protein crystallography or a related discipline
  • Experience in protein purification from recombinant expression systems (bacterial, eukaryotic)
  • Experience in soluble and/or membrane protein biochemistry and structural biology
  • Extensive experience in setting up and optimising crystallisation experiments
  • Proficiency in crystal screening, data collection and processing, structure determination, building and refinement
  • Significant experience in a variety of data integration and processing software packages
  • Demonstrated experience in shell and python scripting
  • Experience in high-throughput crystallography
  • Understanding of GPCR and other integral membrane proteins (transporters, ion channels) structures and mechanisms
  • Experience working in a drug discovery environment where X-ray diffraction structural studies are used to inform ligand design
  • Excellent organisational skills

What’s in it for you?

  • State-of-the-art R&D centre located in the heart of the Cambridge science cluster
  • Competitive compensation package including discretionary cash bonuses
  • Eligible for grants of Restricted Stock Units in Sosei Group Corporation
  • 25 days annual leave in addition to public holidays
  • Employer contribution to pension
  • Private Medical Insurance and a cash plan for dental and optical reimbursement
  • Health and wellbeing benefits including a subsidised individual gym membership
  • Income protection to cover long term absences due to ill health
  • Group Death in Service equal to 4x basic annual salary

Why Sosei Heptares?

At Sosei Heptares, we are dedicated to the pursuit of scientific innovation. Our mission is to make a significant contribution to improving the quality of life and health of people around the world. To achieve this, we will discover, design, and develop the most innovative and effective medicines for patients worldwide, through our world-leading patent-protected technology and platform

Working at Sosei Heptares

The Sosei Heptares R&D centre is a modern, state-of-the-art centre located within easy shuttle reach of Cambridge and Whittlesford Parkway train stations. We offer a collaborative, diverse and inclusive working environment that considers your individual needs and believes in maintaining a sustainable work-life balance. You will be welcomed by a team of colleagues with decades of accumulated experience in their areas of expertise, happy to help you develop your own skills in a highly collaborative environment and who are keen to provide guidance and support in your personal and career development plans.

Our Vision and Values

To become one of Japan’s science and technology-led biopharmaceutical drug discovery champions. To achieve this, we will leverage our global know-how and operating agility to deliver a sustainable pipeline of first or best-in-class therapeutics, ensuring our place amongst the next generation of leading innovators.

We are guided by three fundamental values.

  • Limitless Compassion
  • Unswerving passion
  • Continuous self-innovation

These unchanging set of core values that serves as a guide across all our activities

Join Us!

Autres informations

The successful candidate will be employed by Heptares Therapeutics Ltd, a UK wholly owned subsidiary of Sosei Group Corporation.

Sosei Heptares is committed to building a diverse and ambitious workforce, and to promoting equal opportunities in employment. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment: we do not discriminate based on age, disability, gender reassignment, marriage and civil partnership, pregnancy and maternity, race, religion or belief, sex, sexual orientation, or any other classification prescribed by law.

Applications should include a CV and covering letter, providing a short description of your background and interest in the role. Please apply through our on-line job’s portal with your application in pdf format, quoting reference number 2022-Crystallography-BMS. The closing date for applications is 31st January 2023.

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