Mass Spectrometry Scientist

SoseiHeptares Cambridge GRAN BRETAGNA
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Descrizione azienda

Sosei Heptares (the corporate brand of Sosei Group Corporation) is a research-focused biotechnology group, publicly listed in Japan (TSE: 4565) and with sites in Tokyo, London and Cambridge (UK).

Our mission is to make a significant contribution to improving the quality of life and health of people around the world. To achieve this, we will discover, design and develop the most innovative and effective medicines for patients worldwide, through our world-leading patent-protected technology and platform.

Our primary focus is the discovery and early development of new medicines originating from its proprietary G Protein-Coupled Receptor (GPCR)-targeted StaR® technology and Structure-Based Drug Design (SBDD) platform capabilities. The company is advancing a broad and deep pipeline of novel medicines across multiple therapeutic areas, including CNS, immuno-oncology, gastroenterology, inflammation and other rare/specialty indications.

Our Company has established partnerships with some of the world’s leading pharmaceutical companies, including AbbVie, AstraZeneca, Biohaven, Genentech (Roche), GSK, Novartis, Pfizer and Takeda and additionally with multiple emerging technology companies. Sosei Heptares is headquartered in Tokyo, Japan with corporate and R&D facilities in Cambridge, UK.

Sosei Heptares has approximately 161 employees based at its new R&D research facility at Granta Park. The size of the company ensures a transparent linkage between all activities from early discovery through to clinical development.

Posizione

We are seeking a mass spectrometry scientist to join the Biophysics team at our research facility on Granta Park, Cambridge, UK. Within the Biophysics team, the mass spectrometry group focus on the development and application of mass spectrometry-based assays to characterise proteins with the emphasis on membrane proteins. Additionally, the group develops analytical approaches such as quantitative MS assays to support the drug discovery pipeline.

We expect the applicant to have a good degree of experience in mass spectrometry analysis of biomolecules in order to quickly integrate into this highly motivated and focussed group. After some initial training, the successful candidate will be expected to work independently and will be responsible for the analysis and interpretation of various mass spectrometry data. They will also be involved in one or more support activities to enable the smooth running of the laboratory, such as routine maintenance of HPLCs and mass spectrometers. They may be required to learn other biochemical and biophysical techniques to support projects. The successful candidate will be expected to interact and collaborate effectively with teams across Sosei Heptares to plan experiments, collate data and present results.

This is an exceptional opportunity to participate in pioneering science using mass spectrometry approaches to make significant contributions within an industry-leading drug discovery company.

Responsibilities:

  • The analysis and interpretation of various mass spectrometry data.
  • Involved in one or more support activities to enable the smooth running of the laboratory, such as routine maintenance of HPLCs and mass spectrometers.
  • May be required to learn other biochemical and biophysical techniques to support projects.
  • The successful candidate will be expected to interact and collaborate effectively with teams across Sosei Heptares to plan experiments, collate data and present results.

Requisiti

• Candidates should possess an MSc (or BSc + 2 years industrial experience) with a degree in Analytical Chemistry, Biophysics or a related field with emphasis in mass spectrometry.

• Experience in HPLC methods development (RP, HILIC).

• Highly motivated individual with excellent attention to detail and critical data analysis skills.

• Desire and flexibility in learning new techniques including analytical/biophysical/biochemical methods.

• Very good organisational skills with ability to deliver to tight timelines.

• Excellent communication and team-working ability.

Desirable


• Development and validation of mass spectrometry methods for the quantitation of peptides/small molecules.

• Hands-on experience with intact mass analysis of proteins.

• Good understanding of protein purification and characterisation. Prior experience of working with membrane proteins would be a plus.

• Proteomics experience including database search and preparation of samples from in-gel digests.

• Knowledge of mass spectrometry software such as Xcalibur, Proteome Discoverer, TraceFinder.

Altre informazioni

Applicants must be able to demonstrate proof of the right to work in the United Kingdom.

We offer a competitive salary and benefits package commensurate with qualifications and experience.

Heptares is an equal opportunities employer.

Applications should include a covering letter, providing a short description of the background to their interest in the role, with curriculum vitae including the names and contact details for two referees. Please apply through our on-line job’s portal with your application in pdf format, quoting reference number 2021-4BMS. The closing date for applications is 14th May 2021.

Sosei Heptares does not accept speculative or unsolicited CVs from agencies. All speculative or unsolicited CVs submitted without an agreement in place will be considered Sosei Heptares's property and will not obligate us to pay a referral fee.