Sosei Heptares is a fully integrated biopharmaceutical company focused on bringing life-changing medicines based on world-class science to patients globally. Our vision is to become one of Japan’s global biopharmaceutical champions.

Our global business combines our world-leading GPCR-targeted StaR® technology, structure-based drug design and early development capabilities in the UK with a highly experienced clinical development capability and a commercial operation in Japan.

We are leveraging these capabilities to generate and advance a broad and deep pipeline of novel medicines across multiple therapeutic areas, including neurology, immunology, gastroenterology and inflammatory diseases. We intend to develop these opportunities for patients in Japan and globally both internally and through our partnerships with global biopharmaceutical companies and emerging technology companies.

Sosei Heptares operates from key locations in Tokyo and Osaka (Japan), London and Cambridge (UK) and Seoul (South Korea).

For more information, please visit https://soseiheptares.com/. LinkedIn: @soseiheptaresco | Twitter: @soseiheptaresco | YouTube: @soseiheptaresco

We are seeking a mass spectrometry scientist to join the Biophysics team at our research facility on Granta Park, Cambridge, UK. Within the Biophysics team, the mass spectrometry group focus on the development and application of mass spectrometry-based assays to characterise membrane proteins in support of the drug discovery pipeline.

The successful applicant will have extensive hands-on experience in diverse mass spectrometry techniques to quickly integrate into this highly motivated and focussed group. With appropriate training, the successful candidate will be expected to work independently and will be responsible for the design, performance, analysis and interpretation of various mass spectrometry experiments. They will also be involved in support activities to enable the smooth running of the laboratory. The successful candidate will be expected to interact and collaborate effectively with teams across Sosei Heptares to plan experiments, collate data and present results.

This is an exceptional opportunity to participate in pioneering science using mass spectrometry approaches to make significant contributions within an industry-leading drug discovery company.

Essential Requirements

· Candidates should possess a PhD (or MSc + 2 years industrial experience) with a degree in Analytical Chemistry, Biochemistry, Biophysics, or a related field with emphasis in mass spectrometry.

· Hands-on experience in sample preparation and handling for various quantitative and qualitative MS analyses.

· Experience in HPLC method development.

· Highly motivated, organise individual with excellent attention to detail and critical data analysis skills.

· Desire and flexibility in learning new techniques.

· Very good organisational skills with ability to deliver to tight timelines.

· Excellent communication and team-working ability.

Desirable

· Development and validation of mass spectrometry methods for the quantitation of peptides and small molecules using SRM and/or PRM.

· Hands-on experience with intact mass and native MS analysis of proteins.

· Experience in protein preparation and handling for structural MS studies.

· Experience in developing and performing structural MS analysis (e.g. HDX).

· Good understanding of protein purification and characterisation. Prior experience of working with membrane proteins would be a plus.

· Proteomics experience including database search and preparation of samples from in-gel digests.

What’s in it for you?

· State-of-the-art R&D centre located in the heart of the Cambridge science cluster

· Competitive compensation package including discretionary cash bonuses

· Eligible for grants of Restricted Stock Units in Sosei Group Corporation

· 25 days annual leave in addition to public holidays plus the option to purchase an additional 5 days each year

· Employer contribution to pension

· Private Medical Insurance for employees and family and a cash plan for dental and optical reimbursement

· Health and wellbeing benefits including a subsidised individual gym membership

· Income protection to cover long term absences due to ill health

· Group Death in Service equal to 4x basic annual salary

Working at Sosei Heptares

The Sosei Heptares R&D centre is a modern, state-of-the-art centre located within easy shuttle reach of Cambridge and Whittlesford Parkway train stations. We offer a collaborative, diverse and inclusive working environment that considers your individual needs and believes in maintaining a sustainable work-life balance. You will be welcomed by a team of colleagues with decades of accumulated experience in their areas of expertise, happy to help you develop your own skills in a highly collaborative environment and who are keen to provide guidance and support in your personal and career development plans.

Our Mission, Vision and Values

Our mission is to make life-changing medicines using world-leading science, to achieve our vision of becoming one of Japan’s global biopharmaceutical champions.

We are guided by three fundamental values.

· Limitless Compassion

· Unswerving passion

· Continuous self-innovation

These unchanging set of core values that serves as a guide across all our activities

Join us!

The successful candidate will be employed by Heptares Therapeutics Ltd, a UK wholly owned subsidiary of Sosei Group Corporation.

Sosei Heptares is committed to building a diverse and ambitious workforce, and to promoting equal opportunities in employment. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment: we do not discriminate based on age, disability, gender reassignment, marriage and civil partnership, pregnancy and maternity, race, religion or belief, sex, sexual orientation, or any other classification prescribed by law.

Applications should include a CV and covering letter, providing a short description of the background of your interest in the role, and apply via our on-line jobs’ portal: https://bit.ly/3v7NJh0 in pdf format, quoting reference number 2023-Mass Spectrometry Research Scientist - Biophysics. The closing date for applications is 30th September 2023.

C.K Group are our partnered agency on this role.