Sosei Heptares is an international biopharmaceutical group focused on the design and development of new medicines originating from its proprietary G Protein-Coupled Receptor (GPCR) targeted StaR® technology and Structure-Based Drug Design (SBDD) platform capabilities. The company is advancing a broad and deep pipeline of partnered and in-house drug candidates in multiple therapeutic areas including neurology, immunology, immuno-oncology, gastroenterology and rare/specialty diseases. Sosei Heptares is a world-leader in engineering of functional, stabilized GPCRs in their natural pharmacological conformations (agonist or antagonist), enabling the determination of 3D structures of GPCR-ligand complexes useful for SBDD.

Sosei Heptares has approximately 145 employees based in the new R&D research facility at Granta Park. The size of the company ensures a transparent linkage between all activities from early discovery through to clinical development.

We are seeking an experienced cryo-electron microscopy scientist to join the biophysics group working on GPCR structure determination to enable drug discovery efforts.

At Sosei Heptares we are equipped with a ThermoFisher Glacios 200keV microscope and purpose-built sample preparation facilities. Applicants should be proficient in the preparation and optimisation of sample grids and have expertise in the operation of high end, high voltage electron microscopes, high-resolution data collection including image processing, automated pre-processing pipelines and high-resolution model reconstruction.

Experience of using EM for structure determination of membrane proteins and/or low molecular weight proteins would be a distinct advantage. This is an exceptional opportunity to participate in pioneering science with an Industry-leading Drug Discovery company.

The successful candidate will be expected to work independently, and:

• have a PhD in biochemistry/biophysics or a related discipline and experience in the operation of high end, high voltage electron microscopes.
• take responsibility for electron microscopy and associated equipment at Sosei Heptares, including defining best practices for instrument use, training and supervision of other users, and hardware and software maintenance.
• perform screening of and data-collection for samples by cryo-electron microscopy.
• collaborate with other Sosei Heptares scientists on research projects and prepare and present results (written and oral) to program teams.
• keep up to date with developments in the field, proposing and implementing changes as necessary.
• have strong interpersonal skills and interact effectively with a wide range of staff and collaborators.

Applicants must be able to demonstrate proof of the right to work in the United Kingdom.

We offer a competitive salary and benefits package commensurate with qualifications and experience.

Applications should include a covering letter, providing a short description of the background to their interest in the role, with curriculum vitae including the names and contact details for two referees. Please send your application in pdf format, quoting reference number 2019_1BMS. The closing date for applications is 21st April 2019.