Biochemist

SoseiHeptares Cambridge United Kingdom Biotech

Company Description

Sosei Heptares (the corporate brand of Sosei Group Corporation) is a research-focused biotechnology group, publicly listed in Japan (TSE: 4565) and with sites in Tokyo, London and Cambridge (UK).

Our mission is to make a significant contribution to improving the quality of life and health of people around the world. To achieve this, we will discover, design and develop the most innovative and effective medicines for patients worldwide, through our world-leading patent-protected technology and platform.

Our primary focus is the discovery and early development of new medicines originating from its proprietary G Protein-Coupled Receptor (GPCR)-targeted StaR® technology and Structure-Based Drug Design (SBDD) platform capabilities. The company is advancing a broad and deep pipeline of novel medicines across multiple therapeutic areas, including CNS, immuno-oncology, gastroenterology, inflammation and other rare/specialty indications.

We have established partnerships with some of the world’s leading pharmaceutical companies, including Allergan, AstraZeneca, Daiichi-Sankyo, Genentech (Roche), Novartis, Pfizer and Takeda and additionally with multiple emerging technology companies

Sosei Heptares has approximately 161 employees based at its new R&D research facility at Granta Park. The size of the company ensures a transparent linkage between all activities from early discovery through to clinical development.

Position

We are now seeking a membrane protein biochemist to join the Biochemistry group at our research facility on Granta Park, Cambridge, UK, working on membrane protein biochemical characterisation to enable drug discovery efforts.

At Sosei Heptares we are equipped with state-of-the-art protein expression, purification, SPR, mass-spectrometry, crystallisation and cryoEM facilities. Applicants should have experience in the expression and purification of challenging membrane proteins destined for biochemical, biophysical and structural studies. Applicants with a proven track record of publications related to the expression, purification, and biochemical characterisation of difficult membrane protein targets in peer-reviewed journals would be advantageous.

This is an exceptional opportunity to participate in pioneering science with an industry-leading drug discovery company.

The successful candidate is expected to:

  • Express and purify membrane proteins
  • Perform appropriate quality control analyses and biochemically and biophysically characterise purified membrane proteins
  • Keep up to date, propose, develop, implement and optimise new techniques in the fields of membrane protein expression, purification and biochemical characterisation
  • Work together with scientists responsible for successfully progressing membrane protein targets through Sosei Heptares’ structure-based drug design pipeline
  • Collaborate with other Sosei Heptares scientists on research projects, working closely with molecular biologists, biophysicists, structural biologists, molecular pharmacologists, computational and medicinal chemists
  • Prepare and effectively present results (written and oral) to project teams
  • Have strong interpersonal skills and interact effectively with collaborators across a wide range of disciplines

Requirements

The preferred candidate will have the following:

  • A PhD in biochemistry, biophysics or a related discipline
  • Experience in membrane protein expression, purification and characterisation in either an academic or industry setting
  • Good molecular biology skills
  • Knowledge in prokaryotic and eukaryotic expression vectors
  • Knowledge in expression construct design and engineering to successfully express membrane proteins destined for biochemical, biophysical and structural studies
  • Expertise in the expression of membrane proteins from mammalian and insect cells
  • Expertise in the purification and extensive biochemical characterisation of membrane proteins
  • Experience in the reconstitution of purified membrane proteins in membrane-mimetic environments
  • Familiarity with biochemical and biophysical techniques used to characterise membrane proteins such as luminescence, fluorescence and FRET-based techniques
  • Understanding of the requirements of purified membrane proteins destined for structural (X-ray and/or CryoEM) and biophysical studies (SPR, mass spectrometry)
  • Excellent organisational skills

Other information

The successful candidate will be employed by Heptares Therapeutics Ltd, a UK wholly owned subsidiary of Sosei Group Corporation.

We offer a competitive salary, commensurate with qualifications and experience, and benefits package including pension and healthcare schemes.

Applications should include a covering letter, providing a short description of the background to their interest in the role, with curriculum vitae including the names and contact details for two referees. Please apply through our on-line jobs’ portal with your application in pdf format, quoting reference number 2021-RS-1BMS.

The closing date for applications is 31st December 2021.

Sosei Heptares does not accept speculative or unsolicited CVs from agencies. All speculative or unsolicited CVs submitted without an agreement in place will be considered Sosei Heptares' property and will not obligate us to pay a referral fee.

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We are committed to being transparent about how we collect and use that data and to meeting our data protection obligations. Details about the information we collect, the purposes for data processing, with whom we share personal data, your rights under data protection laws, and further information can be found in our Sosei Heptares Website Privacy Notice https://soseiheptares.com/privacy-policy. By submitting an application online you agree that you have read and understood our Privacy Notice.


Also note that we take the security of your data seriously. We have internal policies and controls in place to ensure that your data is not lost, accidentally destroyed, misused or disclosed, and is not accessed except by our employees in the proper performance of their duties.

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